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Peganone and Hyperglycemia

Result of checking the interaction of drug Peganone and disease Hyperglycemia for safety when used together.

Check result:

Peganone <> Hyperglycemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Phenytoin, particularly in high dosages, may cause hyperglycemia by inhibiting insulin release. The drug may also raise serum glucose levels in diabetic patients. Therapy with phenytoin should be administered cautiously in patients with diabetes mellitus, glucose intolerance, or a predisposition to hyperglycemia. Patients with diabetes mellitus should be monitored more closely during phenytoin therapy, and their antidiabetic regimen adjusted accordingly. The same precautions should also be observed with other hydantoin anticonvulsants (i.e. ethotoin and mephenytoin) because of their structural and pharmacological similarities to phenytoin.

References:

"Product Information. Dilantin (phenytoin)." Parke-Davis, Morris Plains, NJ.
Carter BL, Small RE, Mandel MD, Starkman MT "Phenytoin-induced hyperglycemia." Am J Hosp Pharm 38 (1981): 1508-12
"Product Information. Mesantoin (mephenytoin)" Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Cerebyx (fosphenytoin)." Parke-Davis, Morris Plains, NJ.
Al-Rubeaan K, Ryan EA "Phenytoin-induced insulin insensitivity." Diabet Med 8 (1991): 968-70
"Product Information. Peganone (ethotoin)" Abbott Pharmaceutical, Abbott Park, IL.

Peganone

Generic Name: ethotoin

Brand Name: Peganone

Synonyms: n.a.

What is Peganone?