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Paroxetine Capsules and Renal dysfunction

Result of checking the interaction of drug Paroxetine Capsules and disease Renal dysfunction for safety when used together.

Check result:

Paroxetine Capsules <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Paroxetine may accumulate in renal dysfunction. The mean plasma concentration of paroxetine in patients with creatinine clearance below 30 mL/min has been shown to be approximately four times greater than that in normal patients. Therapy with paroxetine should be administered cautiously in patients with renal impairment. A reduction in the daily dosage is recommended if renal function is severely impaired.

References:

Doyle GD, Laher M, Kelly JG, Byrne MM, Clarkson A, Zussman BD "The pharmacokinetics of paroxetine in renal impairment." Acta Psychiatr Scand Suppl 350 (1989): 89-90
Kaye CM, Haddock RE, Langley PF, Mellows G, Tasker TC, Zussman BD, Greb WH "A review of the metabolism and pharmacokinetics of paroxetine in man." Acta Psychiatr Scand Suppl 350 (1989): 60-75
"Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.

Paroxetine Capsules

Generic Name: paroxetine

Brand Name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: Paroxetine, PARoxetine

What is Paroxetine Capsules?