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Paraflex and Hepatotoxicity

Generic Name: chlorzoxazone
Dosage Forms: n.a.
Other Brand Names: Lorzone , Paraflex , Remular-S , Parafon Forte DSC , Relaxazone, Eze DS, Remular, Strifon Fort

Result of checking the interaction of drug Paraflex and disease Hepatotoxicity for safety when used together.

Check result:

Paraflex <> Hepatotoxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of chlorzoxazone has been associated with rare cases of serious, idiosyncratic hepatocellular toxicity. Therapy with chlorzoxazone should be administered cautiously in patients with preexisting liver disease. All patients receiving chlorzoxazone should be instructed to immediately report any signs and symptoms of hepatic injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine and jaundice, and to discontinue the drug promptly should they occur. Chlorzoxazone therapy should also be withdrawn if abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase, bilirubin) develop.

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