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Pancuronium and Renal dysfunction

Result of checking the interaction of drug Pancuronium and disease Renal dysfunction for safety when used together.

Check result:

Pancuronium <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Many of the non-depolarizing (competitive) neuromuscular blocking agents undergo significant elimination by the kidney. Their effects may, therefore, be prolonged in patients with renal dysfunction. Therapy with these neuromuscular blocking agents should be administered cautiously and initiated at reduced dosages in renally compromised patients, depending on the level of insufficiency. If possible, alternative agents should be considered. Atracurium, rocuronium and vecuronium do not depend on kidney function for clearance and are often the non-depolarizing muscle relaxants of choice in renal failure.

References:

"Product Information. Anectine (succinylcholine)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Nuromax (doxacurium)." Glaxo Wellcome, Research Triangle Park, NC.
American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
"Product Information. Mivacron (mivacurium)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Tracrium (atracurium)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Zemuron (rocuronium)." Organon, West Orange, NJ.
"Product Information. Metubine Iodide (metocurine)." Dista Products Company, Indianapolis, IN.
"Product Information. Norcuron (vecuronium)." Organon, West Orange, NJ.

Pancuronium

Generic Name: pancuronium

Brand Name:

Synonyms: n.a.

What is Pancuronium?