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Oxacillin injection and Renal dysfunction

Result of checking the interaction of drug Oxacillin injection and disease Renal dysfunction for safety when used together.

Check result:

Oxacillin injection <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Oxacillin is partially converted by the liver to active and inactive metabolites, and both parent drug and metabolites are eliminated by the kidney. The serum concentrations of oxacillin and its metabolites may be increased and the half-lives prolonged in patients with significantly impaired renal function. In general, dosage adjustments are not necessary in either renal or hepatic impairment, but the lower range of the usual recommended dosage may be appropriate in patients with severe renal impairment (CrCl < 10 mL/min). Renal and liver function tests should be performed periodically during prolonged therapy.

References:

Bulger RJ, Lindholm DD, Murray JS, Kirby WM "Effects of uremia on methicillin and oxacillin blood levels." JAMA 187 (1964): 319-22
"Product Information. Bactocill (oxacillin)." SmithKline Beecham, Philadelphia, PA.
Jackson EA, McLeod DC "Pharmacokinetics and dosing of antimicrobial agents in renal impairment, part I." Am J Hosp Pharm 31 (1974): 36-52
Schroder E, Ohm HG, Deupmann FJ "The use of oxacillin in high doses and of amphotericin B in acute renal failure." Ger Med Mon 11 (1966): 368-72

Oxacillin injection

Generic Name: oxacillin

Brand Name: Oxacillin Sodium ADD-Vantage, Bactocill

Synonyms: Oxacillin (injection), Oxacillin

What is Oxacillin injection?