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Onmel and Achlorhydria

Result of checking the interaction of drug Onmel and disease Achlorhydria for safety when used together.

Check result:

Onmel <> Achlorhydria

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The absorption of itraconazole from the capsule formulation diminishes with decreased gastric acidity. Patients with achlorhydria should be advised to take itraconazole capsules with 8 oz. of a cola beverage, which has been shown to enhance absorption in AIDS patients with relative or absolute achlorhydria.

References:

"Product Information. Sporanox oral solution (itraconazole)." Janssen Pharmaceutica, Titusville, NJ.
Wishart JM "The influence of food on the pharmacokinetics of itraconazole in patients with superficial fungal infection." J Am Acad Dermatol 17 (1987): 220-3
Smith D, van de Velde V, Woestenborghs R, Gazzard BG "The pharmacokinetics of oral itraconazole in AIDS patients." J Pharm Pharmacol 44 (1992): 618-9
Hardin TC, Graybill JR, Fetchick R, et al "Pharmacokinetics of itraconazole following oral administration to normal volunteers." Antimicrob Agents Chemother 32 (1988): 1310-3
"Product Information. Sporanox (itraconazole)." Janssen Pharmaceutica, Titusville, NJ.
Van Peer A, Woestenborghs R, Heykants J, et al "The effects of food and dose on the oral systemic availability of itraconazole in healthy subjects." Eur J Clin Pharmacol 36 (1989): 423-6
Zimmermann T, Yeates RA, Laufen H, Pfaff G, Wildfeuer A "Influence of concomitant food intake on the oral absorption of two triazole antifungal agents, itraconazole and fluconazole." Eur J Clin Pharmacol 46 (1994): 147-50

Onmel

Generic Name: itraconazole

Brand Name: Onmel, Sporanox, Sporanox PulsePak, Tolsura

Synonyms: n.a.

What is Onmel?