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Normodyne Intravenous and Liver disease

Result of checking the interaction of drug Normodyne Intravenous and disease Liver disease for safety when used together.

Check result:

Normodyne Intravenous <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Labetalol is primarily metabolized by the liver. Although its elimination half-life is not altered in patients with impaired hepatic function, the oral bioavailability is greater due to decreased first-pass metabolism. Dosage adjustments may be necessary for patients with liver disease, particularly when labetalol is administered orally. In addition, the use of labetalol has been rarely associated with hepatic injury, including cholestatic jaundice, hepatitis, and hepatic necrosis. Therapy with labetalol should be administered cautiously in patients with a current or past history of liver disease. Routine monitoring of liver function tests is recommended.

References:

Stumpf J "Fatal hepatotoxicity induced by hydralazine or labetalol." Pharmacotherapy 11 (1991): 415-8
"Product Information. Trandate (labetalol)." Glaxo Wellcome, Research Triangle Park, NC.
Clark JA, Zimmerman HJ, Tanner LA "Labetalol hepatotoxicity." Ann Intern Med 113 (1990): 210-3
Martin LE, Hopkins R, Bland R "Metabolism of labetalol by animals and man." Br J Clin Pharmacol 3 (4 Suppl) (1976): 695-710
"Product Information. Normodyne (labetalol)." Schering Laboratories, Kenilworth, NJ.
Douglas DD, Yang RD, Jensen P, Thiele DL "Fatal labetalol-induced hepatic injury." Am J Med 87 (1989): 235-6
Homeida M, Jackson L, Roberts CJ "Decreased first-pass metabolism of labetalol in chronic liver disease." Br Med J 2 (1978): 1048-50

Normodyne Intravenous

Generic Name: labetalol

Brand Name: Trandate, Normodyne

Synonyms: Normodyne (Oral)

What is Normodyne Intravenous?