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Nicotine Oral, Transdermal and Liver disease

Result of checking the interaction of drug Nicotine Oral, Transdermal and disease Liver disease for safety when used together.

Check result:

Nicotine Oral, Transdermal <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nicotine is primarily metabolized by the liver, and systemic clearance is dependent on liver blood flow. Although data are lacking, impairment of liver function is likely to reduce nicotine clearance to some extent. Patients with liver disease using a nicotine product should be monitored for development of undue adverse effects and signs of nicotine toxicity, including nausea, salivation, cold sweat, palpitation, abdominal pain, diarrhea, headache, dizziness, vomiting, auditory and vision disturbances, tremors, mental confusion, and weakness. If necessary, nicotine dosage should be reduced or the treatment discontinued.

References:

"Product Information. Habitrol (nicotine)." Basel Pharmaceuticals, Summit, NJ.
Neurath GB "Aspects of the oxidative metabolism of nicotine." Clin Investig 72 (1994): 190-5
"Product Information. Nicotrol NS (nicotine)." McNeil Pharmaceutical, Raritan, NJ.
"Product Information. Nicorette (nicotine)." SmithKline Beecham, Philadelphia, PA.
"Product Information. NicoDerm CQ (nicotine)." SmithKline Beecham, Philadelphia, PA.
Benowitz NL, Jacob P, Fong I, Gupta S "Nicotine metabolic profile in man - comparison of cigarette smoking and transdermal nicotine." J Pharmacol Exp Ther 268 (1994): 296-303

Nicotine Oral, Transdermal

Generic Name: nicotine

Brand Name: Leader Nicotine Polacrilex, Nicorelief, Nicorette, Thrive, Commit, Habitrol, Nicoderm C-Q, Nicotine System Kit, Nicoderm CQ, Nicotrol Inhaler, Nicotrol NS

Synonyms: Nicotine Gum and Lozenges, Nicotine

What is Nicotine Oral, Transdermal?