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Nevirapine Suspension and Hemodialysis

Generic Name: nevirapine
Dosage Forms: oral suspension
Other Brand Names: Viramune , Viramune XR

Result of checking the interaction of drug Nevirapine Suspension and disease Hemodialysis for safety when used together.

Check result:

Nevirapine Suspension <> Hemodialysis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nevirapine is partially removed by hemodialysis. In a pharmacokinetic study of nevirapine in patients with renal impairment, six subjects requiring hemodialysis exhibited a 44% reduction in nevirapine systemic exposure (AUC) over a one-week period. There was also evidence of accumulation of nevirapine hydroxy-metabolites in plasma in these patients; however, the clinical significance is unknown. A supplemental dose following each dialysis session is indicated for patients undergoing chronic hemodialysis.

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