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Naltrexone Hydrochloride And Bupropion Hydrochloride and Liver disease

Result of checking the interaction of drug Naltrexone Hydrochloride And Bupropion Hydrochloride and disease Liver disease for safety when used together.

Check result:

Naltrexone Hydrochloride And Bupropion Hydrochloride <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Bupropion is primarily metabolized by the liver. The systemic exposure and half-life of bupropion and its metabolites may be increased in patients with hepatic impairment, and drug accumulation may occur to a greater extent than usual. Therapy with bupropion should be administered cautiously in patients with impaired hepatic function, including mild to moderate hepatic cirrhosis. A reduced dose and/or dosing frequency should be considered. Extreme caution is advised in patients with severe hepatic cirrhosis. A dosage reduction is required in these patients, and the dosage should not exceed 75 mg once a day. All patients with hepatic impairment should be closely monitored for possible adverse effects that could indicate high drug or metabolite levels.

References:

DeVane CL, Laizure SC, Stewart JT, et al. "Disposition of bupropion in healthy volunteers and subjects with alcoholic liver disease." J Clin Psychopharmacol 10 (1990): 328-32
"Product Information. Zyban (bupropion)." Glaxo Wellcome, Research Triangle Park, NC.
Posner J, Bye A, Dean K, Peck AW, Whiteman PD "The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses." Eur J Clin Pharmacol 29 (1985): 97-103
"Product Information. Wellbutrin (bupropion)." Glaxo Wellcome, Research Triangle Park, NC.
Findlay JW, Van Wyck Fleet J, Smith PG, et al. "Pharmacokinetics of bupropion, a novel antidepressant agent, following oral administration to healthy subjects." Eur J Clin Pharmacol 21 (1981): 127-35

Naltrexone Hydrochloride And Bupropion Hydrochloride

Generic Name: bupropion / naltrexone

Brand Name: Contrave

Synonyms: Bupropion and naltrexone, Naltrexone and Bupropion

What is Naltrexone Hydrochloride And Bupropion Hydrochloride?