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Naltrexone Hydrochloride And Bupropion Hydrochloride and Hepatic/renal dysfunction

Result of checking the interaction of drug Naltrexone Hydrochloride And Bupropion Hydrochloride and disease Hepatic/renal dysfunction for safety when used together.

Check result:

Naltrexone Hydrochloride And Bupropion Hydrochloride <> Hepatic/renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Opiate antagonists are metabolized by the liver (naltrexone to an active metabolite) and eliminated by the kidney. Hepatic and renal impairment may reduce the metabolism and clearance of opiate antagonists. Dosage adjustment for single dose administration is not necessary, however, repeated doses in patients with hepatic and/or renal dysfunction may require adjustment.

References:

"Product Information. Revex (nalmefene)." Ohmeda Pharmaceutical Products Division, Liberty Corner, NJ.
"Product Information. Narcan (naloxone)." DuPont Pharmaceuticals, Wilmington, DE.

Naltrexone Hydrochloride And Bupropion Hydrochloride

Generic Name: bupropion / naltrexone

Brand Name: Contrave

Synonyms: Bupropion and naltrexone, Naltrexone and Bupropion

What is Naltrexone Hydrochloride And Bupropion Hydrochloride?