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Nafcillin Sodium and Renal/liver disease

Result of checking the interaction of drug Nafcillin Sodium and disease Renal/liver disease for safety when used together.

Check result:

Nafcillin Sodium <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nafcillin is primarily metabolized by the liver but also partially excreted unchanged by the kidney. The serum concentration of nafcillin may be increased and the half-life prolonged in patients with significantly impaired renal and/or hepatic function. In general, dosage adjustments are not necessary in either renal or hepatic impairment alone, but may be appropriate in patients with both renal and hepatic failure. Renal and liver function tests should be performed periodically during prolonged therapy.

References:

Diaz CR, Kane JG, Parker RH, Pelsor FR "Pharmacokinetics of nafcillin in patients with renal failure." Antimicrob Agents Chemother 12 (1977): 98-101
"Product Information. Unipen (nafcillin)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Marshall JP, Salt WB, Elam RO, et al "Disposition of nafcillin in patients with cirrhosis and extrahepatic biliary obstruction." Gastroenterology 73 (1977): 1388-92
Rudnick M, Morrison G, Walker B, Singer I "Renal failure, hemodialysis, and nafcillin kinetics." Clin Pharmacol Ther 20 (1976): 413-25

Nafcillin Sodium

Generic Name: nafcillin

Brand Name: Unipen, Nallpen

Synonyms: Nafcillin (injection), Nafcillin

What is Nafcillin Sodium?