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Myleran and Seizure disorders

Result of checking the interaction of drug Myleran and disease Seizure disorders for safety when used together.

Check result:

Myleran <> Seizure disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Seizures have been reported in patients receiving high doses of busulfan. Therapy with busulfan should be administered cautiously to patients with a history of a seizure disorder or head trauma or who are receiving other potentially epileptogenic drugs.

References:

Hassan M, Oberg G, Bjorkholm M, Ehrsson H "Influence of anticonvulsant prophylaxis on high-dose busulphan pharmacokinetics (Meeting abstract)." 18th International Congress of Chemotherapy. June 27-July 2, 1993, Stoc (1993): 388
Sureda A, Perez de Oteyza J, Garcia Larana J, Odriozola J "High-dose busulfan and seizures." Ann Intern Med 111 (1989): 543-4
Marcus RE, Goldman JM "Convulsions due to high-dose busulphan." Lancet 2 (1984): 1463
Martell RW, Sher C, Jacobs P, Monteagudo F "High-dose busulfan and myoclonic epilepsy." Ann Intern Med 106 (1987): 173
"Product Information. Myleran (busulfan)." Prasco Laboratories, Cincinnati, OH.
Murphy CP, Harden EA, Thompson JM "Generalized seizures secondary to high-dose busulfan therapy." Ann Pharmacother 26 (1992): 30-1

Myleran

Generic Name: busulfan

Brand Name: Myleran, Busulfex

Synonyms: n.a.

What is Myleran?