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Minoxidil (Systemic) and Ischemic heart disease

Result of checking the interaction of drug Minoxidil (Systemic) and disease Ischemic heart disease for safety when used together.

Check result:

Minoxidil (Systemic) <> Ischemic heart disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Minoxidil commonly produces reflex tachycardia. Angina pectoris may develop or worsen as a result of increased oxygen demands associated with increased heart rate and cardiac output. Therapy with minoxidil should be administered cautiously in patients with coronary insufficiency. The concomitant administration of a beta-adrenergic blocker is often helpful to prevent tachycardia and increased myocardial workload. Minoxidil has not been studied for use in patients who have had a recent myocardial infarction (within the preceding month). It is possible that the reduction of arterial pressure and increase in heart rate produced by minoxidil may further limit blood flow to the myocardium. Minoxidil must be administered under close supervision, also usually given with a diuretic, to prevent serious fluid accumulation. Patients with malignant hypertension and those already receiving guanethidine should be hospitalized when minoxidil is first administered so that they can be monitored to avoid too rapid, or large orthostatic, decreases in blood pressure.

References:

Bennion SD "Chest pain and abnormal electrocardiogram associated with minoxidil." Mil Med 147 (1982): 367-8
Campese VM "Minoxidil: a review of its pharmacological properties and therapeutic use." Drugs 22 (1981): 257-78
Miller DD, Love DW "Drug therapy reviews: evaluation of minoxidil." Am J Hosp Pharm 37 (1980): 808-14
"Product Information. Loniten (minoxidil)." Pharmacia and Upjohn, Kalamazoo, MI.

Minoxidil (Systemic)

Generic Name: minoxidil

Brand Name: Loniten

Synonyms: Minoxidil

What is Minoxidil (Systemic)?