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Midazolam Nasal Spray and Congestive heart failure

Result of checking the interaction of drug Midazolam Nasal Spray and disease Congestive heart failure for safety when used together.

Check result:

Midazolam Nasal Spray <> Congestive heart failure

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

In patients with congestive heart failure, there appears to be a two-fold increase in the elimination half-life, a 25% decrease in the plasma clearance, and a 40% increase in the volume of distribution of midazolam. Therapy with midazolam should be administered cautiously at reduced initial dosages in patients with congestive heart failure, particularly if they are elderly. The possibility of profound and/or prolonged effect should be considered.

References:

"Product Information. Versed (midazolam)." Roche Laboratories, Nutley, NJ.
Patel IH, Soni PP, Fukuda EK, Smith DF, Leier CV, Boudoulas H "The pharmacokinetics of midazolam in patients with congestive heart failure." Br J Clin Pharmacol 29 (1990): 565-9

Midazolam Nasal Spray

Generic Name: midazolam

Brand Name: Versed, Nayzilam

Synonyms: Midazolam

What is Midazolam Nasal Spray?