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Metronidazole Oral, Intravenous and Alcoholism

Result of checking the interaction of drug Metronidazole Oral, Intravenous and disease Alcoholism for safety when used together.

Check result:

Metronidazole Oral, Intravenous <> Alcoholism

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nitroimidazoles (e.g., metronidazole, tinidazole) may inhibit alcohol dehydrogenase and occasionally precipitate a disulfiram-like reaction in patients who consume alcohol while being treated. Symptoms may include nausea, vomiting, flushing, sweating, headache, abdominal cramps, and hypotension. Patients should be instructed to avoid alcohol-containing products during nitroimidazole therapy and for at least 48 to 72 hours after the last dose. Therapy with nitroimidazoles should be administered cautiously in patients who might be prone to acute alcohol intake. An alternative therapy may be appropriate.

References:

"Product Information. Flagyl (metronidazole)." Searle, Skokie, IL.
"Product Information. Tindamax (tinidazole)." Presutti Laboratories Inc, Arlington Heights, IL.
Giannini AJ, DeFrance DT "Metronidazole and alcohol: potential for combinative abuse." J Toxicol Clin Toxicol 20 (1983): 509-15
Harries DP, Teale KF, Sunderland G "Metronidazole and alcohol: potential problems." Scott Med J 35 (1990): 179-80
Alexander I "Alcohol-antabuse syndrome in patients receiving metronidazole during gynaecological treatment." Br J Clin Pract 39 (1985): 292-3
Williams CS, Woodcock KR "Do ethanol and metronidazole interact to produce a disulfiram-like reaction?." Ann Pharmacother 34 (2000): 255-7

Metronidazole Oral, Intravenous

Generic Name: metronidazole

Brand Name: Flagyl, MetroGel, FIRST Metronidazole, Flagyl 375

Synonyms: Metronidazole, MetroNIDAZOLE (Systemic)

What is Metronidazole Oral, Intravenous?