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Metoclopramide Injection and Parkinsonism

Result of checking the interaction of drug Metoclopramide Injection and disease Parkinsonism for safety when used together.

Check result:

Metoclopramide Injection <> Parkinsonism

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Metoclopramide has antidopaminergic effects and may cause parkinsonian-like symptoms such as akinesia, bradykinesia, tremors, pill-rolling motion, cogwheel rigidity, and postural abnormalities including stooped posture and shuffling gait. The onset is usually within the first six months following initiation of therapy but occasionally after longer periods. Symptoms generally subside within 2 to 3 months after drug discontinuation. Therapy with metoclopramide should be administered cautiously, if at all, in patients with Parkinson's disease or parkinsonian symptoms.

References:

"Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Grimes JD "Parkinsonism and tardive dyskinesia associated with long-term metoclopramide therapy." N Engl J Med 305 (1981): 1417
JimenezJimenez FJ, GarciaRuiz PJ, Molina JA "Drug-induced movement disorders." Drug Saf 16 (1997): 180-204
Ganzini L, Casey DE, Hoffman WF, McCall AL "The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders." Arch Intern Med 153 (1993): 1469-75
Sirota RA, Kimmel PL, Trichtinger MD, Diamond BF, Stein HD, Yudis M "Metoclopramide-induced parkinsonism in hemodialysis patients. Report of two cases." Arch Intern Med 146 (1986): 2070-1
Bateman DN, Rawlins MD, Simpson JM "Extrapyramidal reactions with metoclopramide." Br Med J (Clin Res Ed) 291 (1985): 930-2
Miller LG, Jankovic J "Metoclopramide-induced movement disorders. Clinical findings with a review of the literature." Arch Intern Med 149 (1989): 2486-92

Metoclopramide Injection

Generic Name: metoclopramide

Brand Name: Metozolv ODT, Reglan

Synonyms: Metoclopramide

What is Metoclopramide Injection?