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Methyldopa and Hydrochlorothiazide and Psychoses

Result of checking the interaction of drug Methyldopa and Hydrochlorothiazide and disease Psychoses for safety when used together.

Check result:

Methyldopa and Hydrochlorothiazide <> Psychoses

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Rare symptoms of psychoses, such as hallucinations and delirium, and vivid dreams and nightmares have been reported during methyldopa therapy. Therapy with methyldopa should be administered cautiously to patients with a history of or predisposition to these conditions.

References:

Wurzelmann J, Frishman WH, Aronson M, et al "Neuropsychological effects of antihypertensive drugs." Cardiol Clin 5 (1987): 689-701
"Product Information. Aldomet (methyldopa)." Merck & Co, Inc, West Point, PA.
Labbate LA, Holzgang AJ "Manic syndrome after discontinuation of methyldopa." Am J Psychiatry 146 (1989): 1075-6
Tchen P, Luchins DJ, Rose RP "Possibility of depression as a side effect of methyldopa." Am J Psychiatry 147 (1990): 128
Endo M, Hirai KO, Ohara M "Paranoid-hallucinatory state induced in a depressive patient by methyldopa: a case report." Psychoneuroendocrinology 3 (1978): 211-5

Methyldopa and Hydrochlorothiazide

Generic Name: hydrochlorothiazide / methyldopa

Brand Name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50

Synonyms: Hydrochlorothiazide and methyldopa

What is Methyldopa and Hydrochlorothiazide?