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Methyldopa and Hydrochlorothiazide and Hemolytic anemia

Result of checking the interaction of drug Methyldopa and Hydrochlorothiazide and disease Hemolytic anemia for safety when used together.

Check result:

Methyldopa and Hydrochlorothiazide <> Hemolytic anemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hemolytic anemia has occurred rarely during therapy with methyldopa and may be associated with a (+) direct Coombs. Therapy with methyldopa should be administered cautiously to patients with anemia or a predisposition to hemolytic syndromes. Clinical monitoring of hematopoietic function, including a baseline hematological profile, is recommended. If Coombs- positive hemolytic anemia occurs, the cause may be methyldopa and the drug should be discontinued

References:

Nelson RB Jr, Nelson RB III "Methyldopa-associated intravascular hemolysis." Arch Intern Med 137 (1977): 1260-1
Distenfeld A, Florita C, Gelfand ML "Hemolytic anemia induced by alpha-methyldopa." N Y State J Med Feb (1970): 570-3
"Product Information. Aldomet (methyldopa)." Merck & Co, Inc, West Point, PA.
Roy A, Ghosh ML "Coombs positive haemolytic anaemia due to methyldopa." Br J Clin Pract 35 (1981): 54, 58

Methyldopa and Hydrochlorothiazide

Generic Name: hydrochlorothiazide / methyldopa

Brand Name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50

Synonyms: Hydrochlorothiazide and methyldopa

What is Methyldopa and Hydrochlorothiazide?