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Amphotericin b Intravenous, Injection and Electrolyte disturbances

Result of checking the interaction of drug Amphotericin b Intravenous, Injection and disease Electrolyte disturbances for safety when used together.

Check result:

Amphotericin b Intravenous, Injection <> Electrolyte disturbances

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Intravenously administered amphotericin B is nephrotoxic and may commonly cause hypo- or hyperkalemia, hypomagnesemia, and hypocalcemia secondary to renal impairment. Renal function and serum electrolytes should be closely monitored in all patients receiving intravenous therapy with amphotericin B, but in particular, those with preexisting renal and/or electrolyte abnormalities. Mineral and electrolyte supplementation is frequently required. Complications of electrolyte imbalances include muscle weakness, tetany, seizures and cardiac disturbances. Amphotericin B-related electrolyte abnormalities generally improve following cessation of therapy but may persist long after because of the drug's long terminal elimination half-life.

References:

"Amphotericin." Med Lett Drugs Ther 30 (1988): 30-2
Branch R, Jackson E, Jacqz E, et al "Amphotericin-B nephrotoxicity in humans decreased by sodium supplements with coadministration of ticarcillin or intravenous saline." Klin Wochenschr 65 (1987): 500-6
Barton C, Pahl M, Vaziri N, Cesario T "Renal magnesium wasting associated with amphotericin B therapy." Am J Med 77 (1984): 471-4
Branch R "Prevention of amphotericin B-induced renal impairment: a review on the use of sodium supplementation." Arch Intern Med 148 (1988): 2389-94
Maddux M, Barriere S "A review of complications of amphotericin B therapy: recommendations for prevention and management." Drug Intell Clin Pharm 14 (1980): 177-81
Patterson R, Ackerman G "Renal tubular acidosis due to amphotericin B nephrotoxicity." Arch Intern Med 127 (1971): 241-4
Clements J, Peacock J "Amphotericin B revisited: reassessment of toxicity." Am J Med 88 (1990): n22-7
Miller R, Bates J "Amphotericin B toxicity." Ann Intern Med 71 (1969): 1089-95
"Product Information. Fungizone (amphotericin B)." Bristol-Myers Squibb, Princeton, NJ.
Arning M, Scharf R, Schneider W "Prevention of renal failure during long-term treatment with amphotericin-B." Klin Wochenschr 65 (1987): 1108

Amphotericin b Intravenous, Injection

Generic Name: amphotericin b

Brand Name: Fungizone, Fungizone For Tissue Culture, Amphocin

Synonyms: Amphotericin B, Amphotericin B (Conventional)

What is Amphotericin b Intravenous, Injection?