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Methimazole and Hypoprothombinemia

Result of checking the interaction of drug Methimazole and disease Hypoprothombinemia for safety when used together.

Check result:

Methimazole <> Hypoprothombinemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Thioamide antithyroid agents may interfere with the action of vitamin K and have been reported in isolated cases to induce hypoprothombinemia and bleeding. Myelosuppression rarely resulting in thrombocytopenia has also been reported. Therapy with thioamide derivatives should be administered cautiously in patients with significant active bleeding or a hemorrhagic diathesis, including hemostatic and/or coagulation defects associated with hemophilia, vitamin K deficiency, hypoprothombinemia, thrombocytopenia, thrombocytopathy, or severe hepatic impairment. Clinical monitoring of prothrombin time or INR is recommended.

References:

"Product Information. Tapazole (methimazole)." King Pharmaceuticals Inc, Bristol, TN.
Sammon TJ, Peden VH, Witzleben C, King JP "Disseminated intravascular coagulation complicating propylthiouracil therapy. A case description of a 16-year-old girl." Clin Pediatr (Phila) 10 (1971): 739-42
"Product Information. Propylthiouracil (propylthiouracil)." Lederle Laboratories, Wayne, NJ.

Methimazole

Generic Name: methimazole

Brand Name: Tapazole, Northyx

Synonyms: n.a.

What is Methimazole?