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Methergine (Methylergonovine Injection) and Cardiovascular adverse effects

Result of checking the interaction of drug Methergine (Methylergonovine Injection) and disease Cardiovascular adverse effects for safety when used together.

Check result:

Methergine (Methylergonovine Injection) <> Cardiovascular adverse effects

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The amine ergot alkaloids, ergonovine and methylergonovine, can cause serious cardiovascular complications because of their vasospastic effects. Hypertension (more often with ergonovine) has been most commonly reported, particularly when administered IV undiluted or at an excessive rate or when used in conjunction with regional anesthesia or vasoconstrictors. Headaches, seizures, cerebrovascular accidents and death have been associated with the hypertensive episodes. Other, less common adverse effects include acute myocardial infarction, transient chest pains, thrombophlebitis, tachycardia and palpitations. Therapy with ergot alkaloids should generally be avoided, except under special circumstances, in patients with chronic hypertension, preeclampsia or eclampsia, cardiovascular disease, cerebrovascular disease, or peripheral vascular disease. Caution is advised when these agents are administered to patients with venoatrial shunts, mitral valve stenosis, or sepsis. Close monitoring of cardiovascular status is highly recommended during therapy.

References:

"Product Information. Ergotrate Maleate (ergonovine)." Bedford, Bedford, OH.
American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):

Methergine (Methylergonovine Injection)

Generic Name: methylergonovine

Brand Name: Methergine

Synonyms: Methergine (oral and injection), Methergine

What is Methergine (Methylergonovine Injection)?