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Mephyton and Hepatobiliary dysfunction

Result of checking the interaction of drug Mephyton and disease Hepatobiliary dysfunction for safety when used together.

Check result:

Mephyton <> Hepatobiliary dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Phytonadione is fat soluble and requires bile for adequate intestinal absorption. Biliary dysfunction decreases the absorption of phytonadione. Phytonadione is metabolized by the liver and excreted in bile and urine. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of phytonadione. Phytonadione will not correct hypoprothrombinemia due to hepatocellular dysfunction or damage and administration of excessive phytonadione may worsen hepatic function.

References:

Barkhan P, Shearer MJ "Metabolism of vitamin K1 (phylloquinone) in man." Proc R Soc Med 70 (1977): 93-6
Shearer MJ, McBurney A, Barkhan P "Studies on the absorption and metabolism of phylloquinone (vitamin K1) in man." Vitam Horm 32 (1974): 513-42
"Product Information. Mephyton (phytonadione)." Merck & Co, Inc, West Point, PA.
"Product Information. Vitamin K Injection (phytonadione)." Abbott Pharmaceutical, Abbott Park, IL.
Ballard HS, Marcus AJ "Decompensated portal cirrhosis. Effects of large doses of phytonadione." Arch Intern Med 117 (1966): 182-6

Mephyton

Generic Name: phytonadione

Brand Name: Mephyton, Aquamephyton, Konakion, Vitamin K1

Synonyms: n.a.

What is Mephyton?