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Memantine Hydrochloride and Renal impairment

Result of checking the interaction of drug Memantine Hydrochloride and disease Renal impairment for safety when used together.

Check result:

Memantine Hydrochloride <> Renal impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Memantine renal clearance involves active tubular secretion moderated by pH dependent tubular reabsorption and conditions that raise urine pH may increase the plasma levels of memantine. Therapy with memantine should be used cautiously in patients with conditions that raise urine pH, such as renal tubular acidosis or severe infections of the urinary tract. Additionally, memantine should be used with caution in patients with severe renal impairment and a dosage reduction is recommended. No dosage adjustment is needed in patients with mild or moderate renal impairment.

Memantine Hydrochloride

Generic Name: memantine

Brand Name: Namenda, Namenda XR

Synonyms: Memantine

What is Memantine Hydrochloride?