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Amoxicillin, clarithromycin, and lansoprazole and Liver disease

Result of checking the interaction of drug Amoxicillin, clarithromycin, and lansoprazole and disease Liver disease for safety when used together.

Check result:

Amoxicillin, clarithromycin, and lansoprazole <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Lansoprazole is primarily metabolized by the liver. Although the drug is generally well-tolerated, dosage adjustments with cautious titration should be considered in patients with severe hepatic impairment.

References:

"Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc, Deerfield, IL.
Pichard L, Curi-Pedrosa R, Bonfils C, Jacqz-Aigrain E, Domergue J, Joyeux H, Cosme J, Guengerich FP, Maurel P "Oxidative metabolism of lansoprazole by human liver cytochromes P450." Mol Pharmacol 47 (1995): 410-8
Delhotal-Landes B, Flouvat B, Duchier J, Molinie P, Dellatolas F, Lemaire M "Pharmacokinetics of lansoprazole in patients with renal or liver disease of varying severity." Eur J Clin Pharmacol 45 (1993): 367-71
Spencer CM, Faulds D "Lansoprazole. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy in acid- related disorders." Drugs 48 (1994): 404-30

Amoxicillin, clarithromycin, and lansoprazole

Generic Name: amoxicillin / clarithromycin / lansoprazole

Brand Name: Prevpac

Synonyms: Lansoprazole, Amoxicillin, and Clarithromycin

What is Amoxicillin, clarithromycin, and lansoprazole?