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Maxalt-MLT and Renal dysfunction

Generic Name: rizatriptan
Dosage Forms: tablet, orally disintegrating
Other Brand Names: Maxalt , Maxalt-MLT

Result of checking the interaction of drug Maxalt-MLT and disease Renal dysfunction for safety when used together.

Check result:

Maxalt-MLT <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Rizatriptan is excreted in the urine primarily as metabolites but also as unchanged drug. Following oral administration in patients with renal impairment (CrCl = 10 to 60 mL/min/1.73 m2), the plasma concentrations of rizatriptan were not significantly altered compared to healthy controls. In hemodialysis patients (CrCl < 2 mL/min/1.73 m2), however, the area under the plasma concentration-time curve (AUC) was approximately 44% greater than that in controls. Therapy with rizatriptan should be administered cautiously in dialysis patients and patients with significantly impaired renal function. A lower initial dosage may be appropriate.

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