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Maprotiline Hydrochloride and Seizure disorders

Result of checking the interaction of drug Maprotiline Hydrochloride and disease Seizure disorders for safety when used together.

Check result:

Maprotiline Hydrochloride <> Seizure disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of maprotiline is contraindicated in patients with seizure disorders. Maprotiline, a tetracyclic antidepressant, has a greater propensity to cause seizures than the tricyclic antidepressants. The majority of reported cases of maprotiline- related seizures occurred in patients without a history of seizures, although confounding factors were present in some, including the administration of concomitant medications known to lower seizure threshold, rapid dosage escalation, and exceeding the recommended dosage range. Therapy with maprotiline should be administered cautiously in patients with predisposing factors for seizures, such as head trauma, CNS abnormalities, and alcoholism.

References:

Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30
"Product Information. Ludiomil (maprotiline)." Ciba-Geigy Pharmaceuticals, East Hanover, NJ.
DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM "Pharmacotherapy: A Pathophysiologic Approach 4th" Stamford, CT: Appleton & Lange (1999):
Markowitz J, Brown R "Seizures with neuroleptics and antidepressants." Gen Hosp Psychiatry 9 (1987): 135-41

Maprotiline Hydrochloride

Generic Name: maprotiline

Brand Name: Ludiomil

Synonyms: Maprotiline

What is Maprotiline Hydrochloride?