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Lovenox (Enoxaparin Multi-Dose Vials) and Prematurity

Result of checking the interaction of drug Lovenox (Enoxaparin Multi-Dose Vials) and disease Prematurity for safety when used together.

Check result:

Lovenox (Enoxaparin Multi-Dose Vials) <> Prematurity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Some preparations (i.e., multiple-dose vials) of low molecular weight heparin (LMWH) contain benzyl alcohol as a preservative. Benzyl alcohol in bacteriostatic saline intravascular flush and endotracheal tube lavage solutions has been associated with fatalities and severe respiratory and metabolic complications in low-birthweight premature infants. Symptoms include a striking onset of gasping respiration, hypotension, bradycardia, and cardiovascular collapse. The manufacturers recommend that use of these products be avoided in all neonates whenever possible. Nevertheless, many experts feel that, in the absence of benzyl alcohol-free equivalents, the amount of the preservative present in these formulations should not necessarily preclude their use if they are clearly indicated. The American Academy of Pediatrics considers benzyl alcohol in low doses (such as when used as a preservative in some medications) to be safe for newborns. LMWHs are not approved for use in pediatric patients.

Lovenox (Enoxaparin Multi-Dose Vials)

Generic Name: enoxaparin

Brand Name: Lovenox, Lovenox HP, Clexane, Clexane Forte

Synonyms: Lovenox

What is Lovenox (Enoxaparin Multi-Dose Vials)?