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Amlodipine, hydrochlorothiazide, and olmesartan and Renal/liver disease

Result of checking the interaction of drug Amlodipine, hydrochlorothiazide, and olmesartan and disease Renal/liver disease for safety when used together.

Check result:
Amlodipine, hydrochlorothiazide, and olmesartan <> Renal/liver disease
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Olmesartan is eliminated unchanged in the urine and bile. After repeated dosing in patients with severe renal impairment (CrCl < 20 mL/min), the systemic exposure (AUC) was approximately tripled compared to subjects with normal renal function. In patients with moderate hepatic impairment, the AUC increased about 60% relative to that in matched controls. The manufacturer states that no initial dosage adjustment is necessary in patients with moderate to marked renal or hepatic impairment. However, patients should be monitored for undue adverse effects of the drug.

References:
  • "Product Information. Benicar (olmesartan)." Sankyo Parke Davis, Parsippany, NJ.
Amlodipine, hydrochlorothiazide, and olmesartan

Generic Name: amlodipine / hydrochlorothiazide / olmesartan

Brand Name: Tribenzor

Synonyms: Olmesartan, Amlodipine, and Hydrochlorothiazide

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