Lorlatinib and Hepatotoxicity/hepatic impairment
Result of checking the interaction of drug Lorlatinib and disease Hepatotoxicity/hepatic impairment for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:The recommended dose of lorlatinib has not been established for patients with moderate or severe hepatic impairment, therefore, caution is advised if using in these patients. Additionally, severe hepatotoxicity has been reported in patients with risk factors for hepatotoxicity (e.g., taking hepatotoxic drugs such as strong CYP3A inducers). Caution and close monitoring of hepatic function is advised.
Lorlatinib - hepatotoksyczność / zaburzenia czynności wątroby 
Lorlatinib - hepatotoxicidade / insuficiência hepática 
Lorlatinib - hepatotoksisiti / gangguan hepatik 
Lorlatinib - hepatotoksisitas / gangguan hati 
Lorlatinib - epatotossicità / compromissione epatica 
Lorlatinib - hépatotoxicité / insuffisance hépatique 
Lorlatinib - Hepatotoxizität / Leberfunktionsstörung 
Lorlatinib - hepatotoxicidad / insuficiencia hepática 
Lorlatinib - гепатотоксичность / печеночная недостаточность 
Lorlatinib - hepatotoksisite / karaciğer yetmezliği 
Lorlatinib - السمية الكبدية / القصور الكبدي 
Lorlatinib - 肝毒性/肝功能损害