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Lorlatinib and Atrioventricular block

Result of checking the interaction of drug Lorlatinib and disease Atrioventricular block for safety when used together.

Check result:

Lorlatinib <> Atrioventricular block

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

PR interval prolongation and atrioventricular (AV) block can occur in patients receiving lorlatinib, with some reports of Grade 3 AV block that required a pacemaker placement. Patients at risk should have a ECG prior to initiating lorlatinib and should be monitored periodically thereafter. Withhold treatment and resume at a reduced dose or at the same dose in patients who undergo pacemaker placement. Permanently discontinue for recurrence in patients without a pacemaker.

Lorlatinib

Generic Name: lorlatinib

Brand Name: Lorbrena

Synonyms: n.a.

What is Lorlatinib?