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Lorcaserin Extended-Release Tablets and Liver disease

Result of checking the interaction of drug Lorcaserin Extended-Release Tablets and disease Liver disease for safety when used together.

Check result:

Lorcaserin Extended-Release Tablets <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Lorcaserin is extensively metabolized in the liver by multiple enzymatic pathways. In study subjects with varying degrees of hepatic function, lorcaserin peak plasma concentration (Cmax) was reduced by 7.8% and 14.3% in subjects with mild (Child-Pugh score 5 to 6) and moderate (Child-Pugh score 7 to 9) hepatic impairment, respectively, compared to subjects with normal hepatic function. Lorcaserin exposure (AUC) increased by approximately 22% and 30% in patients with mild and moderate hepatic impairment, respectively, and the half-life was prolonged by 59% to 19 hours in patients with moderate hepatic impairment. No dosage adjustment of lorcaserin is required in patients with mild to moderate hepatic impairment. The effect of severe hepatic impairment on the pharmacokinetics of lorcaserin was not evaluated. Therapy with lorcaserin should be administered cautiously in patients with severe hepatic impairment.

Lorcaserin Extended-Release Tablets

Generic Name: lorcaserin

Brand Name: Belviq, Belviq XR

Synonyms: Lorcaserin

What is Lorcaserin Extended-Release Tablets?