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Lorazepam Oral Concentrate and Prematurity

Result of checking the interaction of drug Lorazepam Oral Concentrate and disease Prematurity for safety when used together.

Check result:

Lorazepam Oral Concentrate <> Prematurity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Parenteral medications formulated in multidose vials often contain benzyl alcohol as a preservative. Their use is considered by drug manufacturers to be contraindicated in neonates, particularly premature infants and infants of low birth weight. When used in bacteriostatic saline intravascular flush and endotracheal tube lavage solutions, benzyl alcohol has been associated with fatalities and severe respiratory and metabolic complications in low-birth-weight premature infants. Thus, single-dose formulations should always be used in infants whenever possible. However, many experts feel that, in the absence of benzyl alcohol-free equivalents, the amount of the preservative present in these formulations should not necessarily preclude their use if they are clearly indicated. The American Academy of Pediatrics considers benzyl alcohol in low doses (such as when used as a preservative in some medications) to be safe for newborns. However, the administration of high dosages of these medications must take into account the total amount of benzyl alcohol administered. The level at which toxicity may occur is unknown.

References:

""Inactive" ingredients in pharmaceutical products: update (subject review). American Academy of Pediatrics Committee on Drugs. Available from: URL: http://www.aap.org/policy/re9706.html." Pediatrics 99 (1997): 268-78
"Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Tracrium (atracurium)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Nuromax (doxacurium)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Mesnex (mesna)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Mivacron (mivacurium)." Glaxo Wellcome, Research Triangle Park, NC.

Lorazepam Oral Concentrate

Generic Name: lorazepam

Brand Name: Ativan, Lorazepam Intensol

Synonyms: Lorazepam, LORazepam

What is Lorazepam Oral Concentrate?