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Lomotil (Diphenoxylate and Atropine Solution) and Toxic megacolon

Result of checking the interaction of drug Lomotil (Diphenoxylate and Atropine Solution) and disease Toxic megacolon for safety when used together.

Check result:

Lomotil (Diphenoxylate and Atropine Solution) <> Toxic megacolon

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Decreased intestinal motility and prolonged transit time have resulted in toxic megacolon in patients with acute ulcerative colitis. Paralytic ileus has also occurred. Antiperistaltic agent GI motility and prolongs transit time and therapy should be administered cautiously in these patients.

References:

Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
"Product Information. Imodium (loperamide)." Janssen Pharmaceutica, Titusville, NJ.
"Product Information. Kaopectate (attapulgite)." Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Pepto-Bismol (bismuth subsalicylate)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.

Lomotil (Diphenoxylate and Atropine Solution)

Generic Name: atropine / diphenoxylate

Brand Name: Lomotil, Lonox, Lomocot, Vi-Atro

Synonyms: Lomotil

What is Lomotil (Diphenoxylate and Atropine Solution)?