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Lithium Carbonate ER Tablets and Cardiac disease

Result of checking the interaction of drug Lithium Carbonate ER Tablets and disease Cardiac disease for safety when used together.

Check result:

Lithium Carbonate ER Tablets <> Cardiac disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Lithium should generally not be given to patients with significant cardiovascular disease since the risk of lithium toxicity is high in these patients. Additionally, there have been postmarketing reports of a possible association between lithium therapy and the unmasking of Brugada Syndrome, a disorder characterized by abnormal EKG findings and a risk of sudden death. Lithium should be avoided in patients with this diagnosis or suspicion of it, or that have risk factors, which include unexplained syncope, family history of this syndrome, or family history of unexplained sudden death before the age of 45 years.
Therapy with lithium should be administered with extreme caution in patients with preexisting cardiac disease. Consultation with a cardiologist is highly recommended and cardiac monitoring should be completed before and during treatment.

References:

Steckler TL "Lithium- and carbamazepine-associated sinus node dysfunction: nine-year experience in a psychiatric hospital." J Clin Psychopharmacol 14 (1994): 336-9
Tangedahl TN, Gau GT "Myocardial irritability associated with lithium carbonate therapy." N Engl J Med 287 (1972): 867-9
Reisberg B, Gershon S "Side effects associated with lithium therapy." Arch Gen Psychiatry 36 (1979): 879-87
"Product Information. Eskalith (lithium)." SmithKline Beecham, Philadelphia, PA.
Gadallah MF, Feinstein EI, Massry SG "Lithium intoxication: clinical course and therapeutic considerations." Miner Electrolyte Metab 14 (1988): 146-9
Baldessarini RJ, Lipinski JF "Lithium salts: 1970-1975." Ann Intern Med 83 (1975): 527-33
Ong AC, Handler CE "Sinus arrest and asystole due to severe lithium intoxication." Int J Cardiol 30 (1991): 364-6
"Product Information. Lithobid (lithium)." Ciba Pharmaceuticals, Summit, NJ.
Wilson JR, Kraus ES, Bailas MM, Rakita L "Reversible sinus-node abnormalities due to lithium carbonate therapy." N Engl J Med 294 (1976): 1223-4

Lithium Carbonate ER Tablets

Generic Name: lithium

Brand Name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: Lithium

What is Lithium Carbonate ER Tablets?