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Lipodox and Congestive heart failure

Generic Name: doxorubicin liposomal
Dosage Forms: n.a.
Other Brand Names: Doxil , Lipodox 50 , Lipodox

Result of checking the interaction of drug Lipodox and disease Congestive heart failure for safety when used together.

Check result:

Lipodox <> Congestive heart failure

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Precautions and monitoring of patients administered doxorubicin liposomal are the same as those noted for conventional doxorubicin. Doxorubicin can cause myocardial toxicity leading to congestive heart failure. The incidence of drug-induced congestive heart failure in adults is increased when the total cumulative dose of doxorubicin exceeds 550 mg/m2. Patients with preexisting-existing heart disease, prior irradiation, or previous therapy with doxorubicin or related compounds such as daunorubicin, idarubicin or mitoxantrone are at increased risk of cardiotoxicity at a lower cumulative dose. An electrocardiogram, determination of left ventricular ejection fraction, and/or echocardiogram prior to therapy with doxorubicin, at 400 mg/m2 cumulative dose, and periodically thereafter are recommended.

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