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Levatol and Liver disease

Result of checking the interaction of drug Levatol and disease Liver disease for safety when used together.

Check result:

Levatol <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Penbutolol is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from penbutolol due to decreased drug clearance. Therapy with penbutolol should be administered cautiously in patients with liver disease. Dosage adjustments may be necessary.

References:

"Product Information. Levatol (penbutolol)." Reed and Carnrick, Jersey City, NJ.
Vedin JA, Wilhelmsson C, Maass L, Peterson LE "Pharmacodynamic and pharmacokinetic study of oral and intravenous penbutolol." Eur J Clin Pharmacol 25 (1983): 529-34
Ochs HR, Hajdu P, Greenblatt DJ "Pharmacokinetics and dynamics of penbutolol in humans: evidence for pathway-specific stereoselective clearance." Klin Wochenschr 64 (1986): 636-41

Levatol

Generic Name: penbutolol

Brand Name:

Synonyms: Levatol (Oral)

What is Levatol?