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Letermovir Injection and Renal impairment

Result of checking the interaction of drug Letermovir Injection and disease Renal impairment for safety when used together.

Check result:

Letermovir Injection <> Renal impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hydroxypropyl betadex present in the intravenous letermovir formulation is mainly eliminated by glomerular filtration. Decreased elimination of hydroxypropyl betadex has been reported in the literature in patients with severe renal impairment. Closely monitor serum creatinine levels in patients with CrCl less than 50 mL/min using letermovir injection because accumulation of the intravenous vehicle, hydroxypropyl betadex, could occur. In patients with CrCl greater than 10 mL/min, no dosage adjustment of letermovir is required based on renal impairment. The safety of letermovir in patients with end-stage renal disease (CrCl less than 10 mL/min), including patients on dialysis, is unknown.

Letermovir Injection

Generic Name: letermovir

Brand Name: Prevymis

Synonyms: Letermovir (oral/injection), Letermovir

What is Letermovir Injection?