Drug search by name

Lanoxin Pediatric and Hypokalemia/hypomagnesemia

Result of checking the interaction of drug Lanoxin Pediatric and disease Hypokalemia/hypomagnesemia for safety when used together.

Check result:

Lanoxin Pediatric <> Hypokalemia/hypomagnesemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Potassium and/or magnesium depletion sensitizes the myocardium to digoxin. In patients with hypokalemia or hypomagnesemia, digoxin toxicity may occur despite serum drug concentrations below 2.0 ng/mL. Therapy with digoxin should be administered cautiously in patients with or predisposed to potassium and/or magnesium deficiency, including patients on diuretic therapy; those with primary or secondary aldosteronism (may have low potassium levels); those with severe or prolonged diarrhea or vomiting; those with malnutrition; and renal dialysis patients. Electrolyte imbalances should be corrected prior to initiation of treatment. Serum potassium and magnesium concentrations should be monitored during therapy.

References:

Brater DC, Morrelli HF "Digoxin toxicity in patients with normokalemic potassium depletion." Clin Pharmacol Ther 22 (1977): 21-33
Whang R, Oei TO, Watanabe A "Frequency of hypomagnesemia in hospitalized patients receiving digitalis." Arch Intern Med 145 (1985): 655-6
"Product Information. Lanoxin (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.
Steiness E, Olesen KH "Cardiac arrhythmias induced by hypokalaemia and potassium loss during maintenance digoxin therapy." Br Heart J 38 (1976): 167-72

Lanoxin Pediatric

Generic Name: digoxin

Brand Name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin Pediatric?