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Kyprolis and TLS

Result of checking the interaction of drug Kyprolis and disease TLS for safety when used together.

Check result:

Kyprolis <> TLS

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Cases of tumor lysis syndrome (TLS), including fatal outcomes, have been reported in patients receiving carfilzomib. Patients with multiple myeloma and a high tumor burden should be considered at a greater risk for TLS. Ensure that patients are well hydrated before administration of therapy in Cycle 1, and in subsequent cycles as recommended by the manufacturer. Consider uric acid-lowering drugs in patients at risk for TLS. It is recommended to monitor for evidence of TLS during treatment and manage promptly, including interruption of therapy until resolution of TLS.

Kyprolis

Generic Name: carfilzomib

Brand Name: Kyprolis

Synonyms: n.a.

What is Kyprolis?