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Ketoconazole (Systemic) and Achlorhydria

Result of checking the interaction of drug Ketoconazole (Systemic) and disease Achlorhydria for safety when used together.

Check result:

Ketoconazole (Systemic) <> Achlorhydria

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nizoral (brand of ketoconazole) tablets require acidity for proper dissolution and absorption. Therefore, the drug may not be effective in patients with achlorhydria. Taking the medication with an acidic beverage such as orange or cranberry juice may help, but an alternative antifungal agent should be considered.

References:

Lake-Bakaar G, Tom W, Lake-Bakaar D, et al "Gastropathy and ketoconazole malabsorption in the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 109 (1988): 471-3
Mannisto PT, Mantyla R, Nykanen S, et al "Impairing effect of food on ketoconazole absorption." Antimicrob Agents Chemother 21 (1982): 730-3
"Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ.
Daneshmend TK, Warnock DW, Ene MD, et al "Influence of food on the pharmacokinetics of ketoconazole." Antimicrob Agents Chemother 25 (1984): 1-3
Daneshmend TK "Diseases and drugs but not food decrease ketoconazole "bioavailability"." Br J Clin Pharmacol 29 (1990): 783-4

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand Name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?