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Kapspargo Sprinkle and Liver disease

Result of checking the interaction of drug Kapspargo Sprinkle and disease Liver disease for safety when used together.

Check result:

Kapspargo Sprinkle <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Metoprolol is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from metoprolol due to decreased drug clearance. Therapy with metoprolol should be administered cautiously in patients with liver disease. Dosage adjustments may be necessary.

References:

Silas JH, McGourty JC, Lennard MS, Tucker GT, Woods HF "Polymorphic metabolism of metoprolol: clinical studies." Eur J Clin Pharmacol 28 (1985): 85-8
Regardh C-G, Jordo L, Ervik M, et al "Pharmacokinetics of metoprolol in patients with hepatic cirrhosis." Clin Pharmacokinet 6 (1981): 375-88
Johnson JA, Burlew BS "Metoprolol metabolism via cytochrome p4502d6 in ethnic populations." Drug Metab Dispos 24 (1996): 350-5
Regardh CG, Borg KO, Johansson R, et al "Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man." J Pharmacokinet Biopharm 2 (1974): 347-64

Kapspargo Sprinkle

Generic Name: metoprolol

Brand Name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL

Synonyms: Kapspargo

What is Kapspargo Sprinkle?