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Isosorbide Dinitrate and Hydralazine and Hemodialysis

Result of checking the interaction of drug Isosorbide Dinitrate and Hydralazine and disease Hemodialysis for safety when used together.

Check result:

Isosorbide Dinitrate and Hydralazine <> Hemodialysis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The combined effect of organic nitrates or nitrites with hemodialysis, which often lowers blood pressure, can cause life-threatening hypotension. Therapy with these agents should be administered cautiously in patients requiring hemodialysis. The medication should be withheld before undergoing dialysis, and hemodynamic stability should be established prior to resumption of medication following dialysis. Nitroglycerin and isosorbide dinitrate are moderately dialyzed.

References:

Imamura T, Tamura K, Taguchi T, Minoda M, Seita M "Reduction of nitroglycerin and isosorbide dinitrate by hemodialysis in refractory angina pectoris after acute myocardial infarction." Am J Cardiol 61 (1988): 954-5
Dunetz PS "Dialysis patients and nitrates." Nursing 22 (1992): 4

Isosorbide Dinitrate and Hydralazine

Generic Name: hydralazine / isosorbide dinitrate

Brand Name: BiDil

Synonyms: Hydralazine and isosorbide dinitrate

What is Isosorbide Dinitrate and Hydralazine?