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Isosorbide Dinitrate and Hydralazine and Coronary artery disease

Result of checking the interaction of drug Isosorbide Dinitrate and Hydralazine and disease Coronary artery disease for safety when used together.

Check result:

Isosorbide Dinitrate and Hydralazine <> Coronary artery disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of hydralazine is contraindicated in patients with coronary artery disease. Reflex tachycardia may commonly occur. Palpitations and chest pain have also been reported. Myocardial infarction has been associated with the use of hydralazine.

References:

Packer M, Meller J, Medina N, et al "Provocation of myocardial ischemic events during initiation of vasodilator therapy for severe chronic heart failure." Am J Cardiol 48 (1981): 939-46
Laslett LJ, DeMaria AN, Amsterdam EA, Mason DT "Hydralazine-induced tachycardia and sodium retention in heart failure: hemodynamic and symptomatic correlation by prazosin therapy." Arch Intern Med 138 (1978): 819-20
Koch-Weser J "Hydralazine." N Engl J Med 295 (1976): 320-3

Isosorbide Dinitrate and Hydralazine

Generic Name: hydralazine / isosorbide dinitrate

Brand Name: BiDil

Synonyms: Hydralazine and isosorbide dinitrate

What is Isosorbide Dinitrate and Hydralazine?