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Isosorbide Dinitrate and Hydralazine and Bone marrow suppression

Result of checking the interaction of drug Isosorbide Dinitrate and Hydralazine and disease Bone marrow suppression for safety when used together.

Check result:

Isosorbide Dinitrate and Hydralazine <> Bone marrow suppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hydralazine may rarely cause blood dyscrasias at recommended dosages. Reduction in hemoglobin, red cell count, agranulocytosis, leukopenia, and purpura have been reported. Therapy with hydralazine should be administered cautiously in patients with these preexisting conditions and if such abnormalities develop during the course of therapy, treatment should be discontinued. Monitoring blood counts should be considered for those patients at higher risk.

References:

Widerlov E, Karlman I, Storsater J "Hydralazine-induced neonatal thrombocytopenia." N Engl J Med 303 (1980): 1235
Freestone S, Ramsay LE "Transient monoclonal gammopathy in hydralazine-induced lupus erythematosus." Br Med J 285 (1982): 1536-7
Orenstein AA, Yakulis V, Eipe J, Costea N "Immune hemolysis due to hydralazine." Ann Intern Med 86 (1977): 450-1
"Product Information. Apresoline (hydralazine)." Ciba Pharmaceuticals, Summit, NJ.
Koch-Weser J "Hydralazine." N Engl J Med 295 (1976): 320-3
Harrison BD, Laidlaw ST, Reilly JT "Fatal aplastic anaemia associated with lisinopril." Lancet 346 (1995): 247-8
Macleod WN "Anaemia in the hydrallazine-induced lupus syndrome." Scott Med J 28 (1983): 181-2

Isosorbide Dinitrate and Hydralazine

Generic Name: hydralazine / isosorbide dinitrate

Brand Name: BiDil

Synonyms: Hydralazine and isosorbide dinitrate

What is Isosorbide Dinitrate and Hydralazine?