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Isoniazid, pyrazinamide, and rifampin and Gout

Result of checking the interaction of drug Isoniazid, pyrazinamide, and rifampin and disease Gout for safety when used together.

Check result:

Isoniazid, pyrazinamide, and rifampin <> Gout

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of pyrazinamide is contraindicated in patients with acute gout. Pyrazinamide inhibits the renal excretion of uric acid, which may frequently result in precipitation or exacerbation of gout. Therapy with pyrazinamide should be administered cautiously in patients with hyperuricemia or a history of gout. Serum uric acid levels should be monitored regularly, and appropriate measures (e.g., administration of uricosuric agents) taken to prevent the development of gout. If gouty arthritis occurs, pyrazinamide should be discontinued.

References:

"Product Information. Pyrazinamide (pyrazinamide)." VersaPharm Inc, Marietta, GA.
Amodio MI, Bengualid V, Lowy FD "Development of acute gout secondary to pyrazinamide in a patient without a prior history of gout." DICP 24 (1990): 1115-6

Isoniazid, pyrazinamide, and rifampin

Generic Name: isoniazid / pyrazinamide / rifampin

Brand Name: Rifater

Synonyms: n.a.

What is Isoniazid, pyrazinamide, and rifampin?