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Isoniazid Oral Solution and Liver disease

Result of checking the interaction of drug Isoniazid Oral Solution and disease Liver disease for safety when used together.

Check result:

Isoniazid Oral Solution <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Isoniazid is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from isoniazid due to decreased drug clearance. Dosage reductions are recommended in these patients.

References:

Acocella G, Bonollo L, Garimoldi M, et al "Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease." Gut 13 (1972): 47-53
"Product Information. Nydrazid (isoniazid)" Apothecon Inc, Princeton, NJ.
Weber WW, Hein DW "Clinical pharmacokinetics of isoniazid." Clin Pharmacokinet 4 (1979): 401-22
"Product Information. INH (isoniazid)." Ciba Pharmaceuticals, Summit, NJ.
Reed MD, Blumer JL "Clinical pharmacology of antitubercular drugs." Pediatr Clin North Am 30 (1983): 177-93
Ellard GA, Gammon PT "Pharmacokinetics of isoniazid metabolism in man." J Pharmacokinet Biopharm 4 (1976): 83-113

Isoniazid Oral Solution

Generic Name: isoniazid

Brand Name: Nydrazid

Synonyms: Isoniazid

What is Isoniazid Oral Solution?