IsonaRif and Liver disease
Result of checking the interaction of drug IsonaRif and disease Liver disease for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Isoniazid is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from isoniazid due to decreased drug clearance. Dosage reductions are recommended in these patients.
- Acocella G, Bonollo L, Garimoldi M, et al "Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease." Gut 13 (1972): 47-53
- "Product Information. Nydrazid (isoniazid)" Apothecon Inc, Princeton, NJ.
- Weber WW, Hein DW "Clinical pharmacokinetics of isoniazid." Clin Pharmacokinet 4 (1979): 401-22
- "Product Information. INH (isoniazid)." Ciba Pharmaceuticals, Summit, NJ.
- Reed MD, Blumer JL "Clinical pharmacology of antitubercular drugs." Pediatr Clin North Am 30 (1983): 177-93
- Ellard GA, Gammon PT "Pharmacokinetics of isoniazid metabolism in man." J Pharmacokinet Biopharm 4 (1976): 83-113
Generic Name: isoniazid / rifampin
Brand Name: IsonaRif, Rifamate
Synonyms: n.a.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Rifampin is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from rifampin due to decreased drug clearance. In addition, the accumulation of rifampin may result in hyperbilirubinemia because rifampin competes with bilirubin for uptake by hepatocytes. Dosage adjustments are recommended in patients with liver disease. Withdrawal of rifampin therapy may be required if serum bilirubin is persistently high.
- "Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
- Loos U, Musch E, Jensen JC, et al "Pharmacokinetics of oral and intravenous rifampicin during chronic administration." Klin Wochenschr 63 (1985): 1205-11
- Nitti V, Virgilio R, Patricolo MR, Iuliano A "Pharmacokinetic study of intravenous rifampicin." Chemotherapy 23 (1977): 1-6
- Acocella G "Clinical pharmacokinetics of rifampicin." Clin Pharmacokinet 3 (1978): 108-27
Generic Name: isoniazid / rifampin
Brand Name: IsonaRif, Rifamate
Synonyms: n.a.
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