Drug search by name

Ifosfamide Intravenous and Renal dysfunction

Result of checking the interaction of drug Ifosfamide Intravenous and disease Renal dysfunction for safety when used together.

Check result:

Ifosfamide Intravenous <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Ifosfamide is primarily eliminated by the kidney. Approximately 12% to 18% of ifosfamide is excreted unchanged in the urine. Additionally, iIfosfamide is both nephrotoxic and urotoxic. Hemorrhagic cystitis due to metabolites excreted in the urine can develop during therapy with ifosfamide. Adequate hydration and use of a prophylactic agent such as mesna prior to each course of ifosfamide therapy can reduce bladder irritation and hematuria. Clinical signs of renal toxicity such as elevation in BUN or serum creatinine or decrease in creatinine clearance have been reported. Therapy with ifosfamide should be administered cautiously in patients with a history of or predisposition to cystitis or impaired renal function. Close clinical monitoring of serum and urinary chemistries is recommended.

References:

"Product Information. Ifex (ifosfamide)." Bristol-Myers Squibb, Princeton, NJ.
Kramer A, Goldschmidt H, Hahn U, Andrassy K "Progressive renal failure in two breast cancer patients after high- dose ifosfamide." Lancet 344 (1994): 1569
Moncrieff M, Foot A "Fanconi syndrome after ifosfamide." Cancer Chemother Pharmacol 23 (1989): 121-2
Fujita J, Matsumoto K, Kakizoe T, Murase T "Prevention of ifosfamide-induced hemorrhagic cystitis by continuous bladder irrigation." Urology 18 (1981): 250-1
Patterson WP, Khojasteh A "Ifosfamide-induced renal tubular defects." Cancer 63 (1989): 649-51
Beckwith C, Flaharty KK, Cheung AK, Beatty PG "Fanconi's syndrome due to ifosfamide." Bone Marrow Transplant 11 (1993): 71-3
Skinner R, Pearson AD, Price L, Coulthard MG, Craft AW "Nephrotoxicity after ifosfamide." Arch Dis Child 65 (1990): 732-8
Goren MP, Wright RK, Horowitz ME, Pratt CB "Ifosfamide-induced subclinical tubular nephrotoxicity despite mesna." Cancer Treat Rep 71 (1987): 127-30
Garcia AA "Ifosfamide-induced Fanconi syndrome." Ann Pharmacother 29 (1995): 590-1

Ifosfamide Intravenous

Generic Name: ifosfamide

Brand Name: Ifex

Synonyms: Ifosfamide

What is Ifosfamide Intravenous?