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Ifosfamide Intravenous and CNS toxicity

Result of checking the interaction of drug Ifosfamide Intravenous and disease CNS toxicity for safety when used together.

Check result:

Ifosfamide Intravenous <> CNS toxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Administration of ifosfamide can cause CNS toxicity and other neurotoxic effects. The risk of CNS toxicity and other neurotoxic effects necessitates careful monitoring of the patient. Neurologic manifestations consisting of somnolence, confusion, hallucinations, blurred vision, psychotic behavior, and extrapyramidal symptoms, have been reported following ifosfamide therapy. There have also been reports of peripheral neuropathy associated with ifosfamide Episodes of depressive psychoses and hallucinations have been reported during ifosfamide therapy. These neurological symptoms are usually reversible, but ifosfamide should be discontinued and supportive care maintained until symptoms completely resolve. Therapy with ifosfamide should be administered cautiously in patients with a history of or predisposition to psychotic episodes.

References:

Cameron JC "Ifosfamide neurotoxicity. A challenge for nurses, a potential nightmare for patients." Cancer Nurs 16 (1993): 40-6
Curtin JP, Koonings PP, Gutierrez M, Schlaerth JB, Morrow CP "Ifosfamide-induced neurotoxicity." Gynecol Oncol 42 (1991): 193-6;disc. 191-2
Miller LJ, Eaton VE "Ifosfamide-induced neurotoxicity: a case report and review of the literature." Ann Pharmacother 26 (1992): 183-7
"Product Information. Ifex (ifosfamide)." Bristol-Myers Squibb, Princeton, NJ.

Ifosfamide Intravenous

Generic Name: ifosfamide

Brand Name: Ifex

Synonyms: Ifosfamide

What is Ifosfamide Intravenous?